Pulmonary Arterial Hypertension

  • Living with pulmonary arterial hypertension (PAH) can be challenging, but having educational resources shouldn’t have to be. This is why UPTRAVIPath was created—to be an educational resource available at your convenience to help reinforce your understanding of PAH and UPTRAVI® during your treatment journey.
  • Treating PAH
    In this video, your doctor reinforces important topics, such as:
Understanding PAH
Treatment with UPTRAVI®
Caregiver information
Additional resources and support

Consider sharing this video with your loved ones so they can better understand PAH and how best to support you.

What is UPTRAVI®?

  • UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.
  • UPTRAVI® can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.
  • It is not known if UPTRAVI® is safe and effective in children.
  • Living with pulmonary arterial hypertension (PAH) can be challenging, but having educational resources shouldn’t have to be. This is why UPTRAVIPath was created—to be an educational resource available at your convenience to help reinforce your understanding of PAH and UPTRAVI® during your treatment journey.

Your UPTRAVIPath Booklet This helpful booklet can be downloaded and used as a guide for learning about PAH and treatment with UPTRAVI®. You can also use this booklet to follow along as you watch the video from your doctor. You'll review important topics that you have covered in your office visit such as dosing, titration, potential side effects, and treatment goals..

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What is UPTRAVI®?

UPTRAVI® (selexipag) is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1), which is high blood pressure in the arteries of your lungs.

UPTRAVI® can help delay (slow down) the progression of your disease and lower your risk of being hospitalized for PAH.

It is not known if UPTRAVI® is safe and effective in children.

IMPORTANT SAFETY INFORMATION
  • Do not take UPTRAVI® if you take gemfibrozil because this medicine may affect how UPTRAVI® works and cause side effects
  • Do not take UPTRAVI® if you are allergic to selexipag or any of the ingredients in UPTRAVI®

  • Before you take UPTRAVI®, tell your healthcare provider about all your medical conditions, including if you:

    • Have liver problems
    • Have narrowing of the pulmonary veins (veins in your lungs). This is called pulmonary veno-occlusive disease (PVOD)
    • Are pregnant or plan to become pregnant. It is not known if UPTRAVI® will harm your unborn baby
    • Are breastfeeding or plan to breastfeed. It is not known if UPTRAVI® passes into your breast milk. You and your doctor should decide if you will take UPTRAVI® or breastfeed. You should not do both
    • Are taking any other prescription or over-the-counter medicines, vitamins, or herbal supplements
What are the possible side effects of UPTRAVI®?

The most common side effects are:

  • Headache
  • Diarrhea
  • Jaw pain
  • Nausea
  • Muscle pain
  • Vomiting
  • Pain, redness or swelling at the injection
    site with UPTRAVI® for injection
  • Pain in arms or legs
  • Temporary reddening of the skin (flushing)
  • Joint pain
  • Low red blood cell count
  • Less appetite than usual
  • Rash

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all the possible side effects of UPTRAVI®. For more information, ask your doctor or pharmacist.

You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Keep UPTRAVI® and all other medicines away from children.

What other medicines might interact with UPTRAVI®?

UPTRAVI® and other medicines may affect each other, causing side effects. Tell your doctor about all the medicines you are taking. Do not start any new medicine until you check with your doctor.

How should I take UPTRAVI®?

UPTRAVI® Tablets

  • Take UPTRAVI® exactly as your doctor tells you to take it. Usually, your doctor will have you take UPTRAVI® twice a day. Taking UPTRAVI® with food may help you tolerate UPTRAVI® better
  • Swallow UPTRAVI® tablets whole. Do not split, crush, or chew tablets
  • Tell your doctor if you have any form of liver disease. Your doctor may need to change your dose of UPTRAVI®
  • UPTRAVI® is measured in micrograms (mcg). Tablets come in the following strengths: 200, 400, 600, 800, 1000, 1200, 1400, and 1600 mcg

UPTRAVI® given by intravenous (IV) injection

  • Your healthcare provider will give you UPTRAVI® into your vein through an intravenous (IV) line
  • Your healthcare provider will decide how much UPTRAVI® for injection you will receive each day based on your current dose of UPTRAVI® tablets
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